Big, vague, or intrusive thoughts I have at the moment.

Can we run a real field trial on a large-scale geoengineering effort like SAI by the end of this decade?
Can we reduce the amount of capital in DAFs (~$300B) by 20% in the next 10 years?
Can we extend reproductive aging/ovarian health in women by >10% by 2050?
Can we see healthy human lifespan extend another ~20% by 2050?
Can we build a (human?) neuron-derived CPU that can run…Doom?
What will capital allocation look like in the post AI era? What will be the moat?
How can we re-grow cartilage, tendons/ligaments, and general body parts with minimal nutrient/blood supply?
Who are the great talent scouts after folks like Tyler Cowen or Alexey Guzey?
Can we cure all/most (>90%) of all rare diseases by 2040?
How pre-historic will we look to our ancestors in 2126?
Will >10% of humans be uploaded/substrate-independent by 2050?
Will human relationships/partnerships fade away, or stay mostly the same, post-AGI?
Will OpenAI Foundation be able to deploy over 20% of their capital ($30-50B) in the next 5 years?
Can we make a drug to fix TMD/J, that doesn’t involve injecting a ton of botox?
PE/VC was born over 80 years ago. What will the 21st century’s big financial instrument be? It probably isn’t the SPAC…
What is “the next CAA“?